Deletion of iNOS gene impairs mouse fracture healing
نویسندگان
چکیده
منابع مشابه
Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts. C5aR1 induces osteoblast migration, cytokine generation and osteoclastogenesis, however, the exact role of C5aR1-mediated signaling in osteoblasts is not entirely kn...
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BACKGROUND Melatonin, the major pineal hormone, is known to regulate distinct physiologic processes. Previous studies have suggested that it supports skeletal growth and bone formation, most probably by inhibiting bone resorption. There is no information, however, whether melatonin affects fracture healing. We therefore studied in a mouse femur fracture model the influence of melatonin on callu...
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Gastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was cond...
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BACKGROUND Although the capacity of exogenous PTH1-34 to enhance the rate of bone repair is well established in animal models, our understanding of the mechanism(s) whereby PTH induces an anabolic response during skeletal repair remains limited. Furthermore it is unknown whether endogenous PTH is required for fracture healing and how the absence of endogenous PTH would influence the fracture-he...
متن کاملFracture healing
Those of us who have experienced a significant fracture likely recall first the pain of the injury, then we often focus our attention on the prospect of time in a cast or other form of extended immobilization. We imagine the discomfort and limitations that will ensue, and after all else settles down, we often wonder, “How strong are my bones anyway, and will I fracture again?” Nature, on the o...
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ژورنال
عنوان ژورنال: Bone
سال: 2005
ISSN: 8756-3282
DOI: 10.1016/j.bone.2004.10.002